Imagine this: a company-wide lockout to the company CRM, like Salesforce, because the organization's external admin attempts to disable MFA for themselves. They don't think to consult with the security team and don't consider the security implications, only the ease which they need for their team to use their login.
This CRM, however, defines MFA as a top-tier security setting; for example,
http://dlvr.it/SW8bZ0
http://dlvr.it/SW8bZ0